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Botox is a neurotoxin produced by Clostridium botulinum, and its most commonly recognized for its cosmetic application to reduce fine lines and wrinkles

The observed synergistic effect is attributed to their combined ability to regulate multiple intracellular signaling pathways implicated in cystogenesis

In conclusion, we found for the first time that LC and TAU have synergistic inhibitory effects on the proliferation and calcification of VSMCs and that the up-regulation of TAUT expression and TAU uptake by LC in VSMCs may be involved in the synergistic action

Perturbed sphingolipid and phospholipid metabolism led to the upregulation of apoptogenic ceramides and the downregulation of lipids involved in vital cerebral functions, such as neurotransmission, anti-inflammation, and synaptic refinement