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Buchanan and colleagues reviewed the limited available preclinical and clinical data and concluded that E-cigarette use is associated with inflammation, oxidative stress, and haemodynamic imbalance leading to increased cardiovascular disease risk. Current evidence is available primarily from acute studies and the effects of chronic exposure remain an urgent research question

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"US tobacco control: public health, political economy, or morality policy?" Review of Policy Research 25.5 (2008): 393-410