We found that cisplatin treatment caused a decrease in mitochondrial biogenesis (PGC-1, NRF-1, TFAM, mtDNA, ND1), mitochondrial mass (Porin and Citrate synthase activity) and fusion index (MFN2, Drp1), together with changes in the expression of autophagy-related genes (AKT/FoxO pathway, Atg1, Beclin1, LC3AII, p62) and enhanced ROS production (PRX III, MnSOD)
Gopal Grandhige, MD and his team build that plan around each individual, factoring in where they are today and where they want to be
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