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The rationale was to simultaneously inhibit HIF-1 signaling and VEGF-mediated angiogenesis, two key pathways driving tumor growth under hypoxic conditions

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Naunyn-Schmiedebergs Arch Pharmacol 397(11):81658188 Ali I, Padhiar AA, Wang T, He L, Chen M, Wu S, Zhou Y, Zhou G (2022) Stem cell-based therapeutic strategies for premature ovarian insufficiency and infertility: a focus on aging