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Due to the extensive diversity of TCRs and the complexity of antigen-epitope-TCR interactions (where a single antigen can contain multiple epitopes, each potentially recognized by a variety of TCRs), our current results cannot directly clarify the nature of antigen specificity in CD4 and CD8 T cells within COPD airways

For ethical issues, the most obvious is that it could be seen as hypocritical

IARC Monogr Eval Carcinog Risks to Humans Volume 100: Islami F, Moreira DM, Boffetta P, Freedland SJ (2014) A systematic review and meta-analysis of tobacco use and prostate cancer mortality and incidence in prospective cohort studies