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The identification of virulence genes for PCOS-associated endometrial carcinoma was also analyzed by AI algorithms LASSO, SVM, and the topological matrix, indicating both NAA15 linked to sedentary behavior and ENPP2 in hormonal response within PCOS were the novel biomarker for endometrial carcinoma [130, 131]

They demonstrated these PCOS patients have significantly lower total LC (40.5 5.7 mol/L

The C677T variant specifically results in a 30-70% reduction in enzyme activity, likely due to the fact that the alanine to valine amino acid change makes the overall enzyme more heat-sensitive

Cell Rep (2019) 29:273144 e4