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Nrf2 translocates to the nucleus and interacts with the antioxidant response element (ARE) of target genes, resulting in expression of antioxidant genes, which induces an antioxidant response shown to be beneficial for several human conditions 48

As a result of the BCAT reaction, three different -keto acids are produced and are oxidized using a common branched-chain -keto acid dehydrogenase (BCKD) complex, yielding the three different CoA derivatives

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