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Inhibition of NADPH oxidase activation by apocynin rescues seizure-induced reduction of adult hippocampal neurogenesis

Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism

In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]

Furthermore, the absence of standardized formulations complicates dose uniformity and treatment reproducibility, as differences in concentration, excipients, or stability across preparations can materially influence therapeutic efficacy and safety outcomes