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Beyond transcriptional regulation by factors like Nrf2, GPX4 protein abundance and stability are finely regulated by complex post-translational modifications and protein interaction networks

In particular, while several studies suggest that -3 PUFA consumption has protective effects on the development of autoimmune thyroiditis [122], others demonstrate that exposure to pollutants (especially heavy metals) that contaminate fish is associated with an increased risk of autoimmunity and thyroid dysfunction [121,124,125,126]

Persistent bacterial infection aggravates the oxidative stress response in wounds and inactivates the functions of some enzymes such as GPX4, which may explain why Se@PA MN did not significantly increase GPX4 activity and levels