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It has been observed that glutamate production through the appropriate function of GDH pathway has a role in the mitochondrial retrograde signaling that affects changes in nuclear gene expression related to nutrient sensing and TOR signaling [26, 98], aging [99, 100] metabolism [20] and as recently shown, in different types of cancer [101,102,103,104,105,106,107,108]

The primary antibodies used were mouse monoclonal anti-keratin 20 (Abcam, ab854, 1:200), goat polyclonal anti-E-cadherin (R&D Systems, AF748, 1:500), goat polyclonal anti-uroplakin 3a (Santa Cruz, sc-15186, 1:500), mouse monoclonal anti-uroplakin 3a (Fitzgerald, 10R-U103a, 1:50), rabbit polyclonal anti-p63 (GeneTex, GTX102425, 1:1,000), rabbit monoclonal anti-K5 (Abcam, ab150074, 1:100) and mouse monoclonal anti-keratin 14 (Santa Cruz, sc-53253, 1:50)

This is one mechanism linking methylation dysfunction to elevated catecholamines, histamine intolerance, and impaired xenobiotic clearance

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