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2.2 Environmental factors Multiple environmental exposures contribute to the onset and progression of UC by altering gut microbiota composition, compromising epithelial barrier integrity, and modulating mucosal immunity

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Kallaur AP, Lopes J, Oliveira SR, Simo AN, Reiche EM, de Almeida ER, et al

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A meta-analysis of probiotic efficacy for Gastrointestinal diseases

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This escalation should only occur if the lower dose is well-tolerated and additional benefit is needed to achieve treatment goals

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