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Interestingly, the previously unresolved region of DET1 spanning 7-11, which we named the claw, was found to bind to the backside of the Ube2e family members in the DDD-E2 complex (Supplementary Figs

however, this restoration does not consistently correlate with clinical improvement, highlighting the importance of early intervention (Seton et al., 2023)

Preclinical and clinical studies have demonstrated its efficacy in reducing body weight both as a monotherapy and in combination with GLP-1 receptor agonists such as semaglutide, highlighting its potential as a next-generation therapeutic agent for obesity and metabolic syndrome management