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FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, has been found to elevate intracellular GSH levels and decrease iron accumulation when administered as a pre-treatment (166)

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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau