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We do not contend that our method is superior to those proposed before us

Although the effect of smoking on survival was not statistically significant due to the small number of non-smoking patients (5 cases), clinically, a higher percentage of advanced laryngeal cancer patients were smokers

Leveraging self-reported symptoms as listed under the World Health Organizations International Classifications of Diseases and Injuries (ICD) 10th Revision 5 or the American Psychiatric Associations Diagnostic and Statistical Manual Fifth Edition (DSM-5) 6 to diagnose nicotine dependence, researchers have traditionally relied on self-report measures to assess perceived dependence on TNPs

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