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[2] When to Seek Further Medical Advice About B12 Patients should maintain regular contact with their GP or healthcare team throughout B12 treatment, but certain situations warrant urgent medical review

PMID 22179958

While full restoration to youthful levels isnt guaranteed and NAD+ therapy research in humans is still a bit limited, there are studies that support its superiority over diet and exercise alone in significantly raising NAD+ concentrations and promoting healthier aging, especially after 40 when natural production declines sharply

What is pernicious anemia, and how is it related to Vitamin B12 deficiency