A comprehensive history should also include menstrual and sexual history, medical history with emphasis on other chronic pain disorders (i.e., fibromyalgia, irritable bowel syndrome, migraines, endometriosis, vulvodynia, etc.), surgical history, medication use and allergies, and use of tobacco, alcohol, and drugs

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These reactions often improve with proper injection technique and site rotation protocols
Subcutaneous delivery allows for a slow and sustained release from the tissue, with a proven track record of efficient methylcobalamin B12 delivery