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Anticholinergic drugs and drugs act on autonomic ganglia

With combustible tobacco the primary cancer is lung because people are inhaling, but with smokeless use, its primarily in the oral region, [which is] why were seeing a lot of cancers associated with smokeless tobacco around the oral cavity. In addition to being deadly, oral cancers often have devastating effects on a persons appearance, as surgeries to remove cancerous lesions often require removal of portions of the face

doi: 10.1016/j.drugalcdep.2014.03.003