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Experiments have shown that adiponectin, which is secreted by adipocytes, can significantly reduce the expression of PINK1 and Parkin induced by oxidative stress, thereby inhibiting mitophagy and apoptosis caused by mitophagy in C2C12 myoblasts, which provides a new idea for the diagnosis and treatment of skeletal muscle diseases such as sarcopenia and early-onset myopathies [274]

Trivalent iron (Fe 3+ ) in food must first be reduced to divalent iron (Fe 2+ ) before passing via divalent metal transporter 1 (DMT1) into epithelial cells

doi: 10.1152/japplphysiol.00945.2010 Goldstein AL, Hannappel E, Sosne G, Kleinman HK

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