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The development of blood-brain barrier permeable AT 4 receptor agonists and antagonists presents a novel and promising new strategy for the treatment of several of these clinical dysfunctions (174177)

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(2018) demonstrated that BPC-157 accelerated blood vessel formation in a chick chorioallantoic membrane (CAM) assay and in rat cutaneous wound models, quantified by increased CD34+ vessel density and VEGF (vascular endothelial growth factor) expression at the wound site (Seiwerth et al., 2018, Current Pharmaceutical Design