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J Allergy Clin Immunol 1994

5/16 inch (8mm): This is an excellent, all-purpose length

This is concomitant with an enhancement in cytokine release

7 Clinical outcomes of pharmacotherapy To date, numerous clinical studies including double- or single-blinded randomized clinical trials and split-face studies have been conducted to assess the therapeutic effect of various topical conventional and novel formulations in melasma management as summarized in Table 3