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This regulatory function occurs via macrophage polarization in response to both internal and external environmental or pathological stimuli (Guillermo Arango and Albert, 2014)
The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference