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However, when performing a similar pH titration with the U597C variant minimal changes in the formation of the thiolate-FAD charge transfer are observed (Figure 9A) suggesting both that the 571 histidine residue is the acting general base and the C159 residue is highly shielded from solvent

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Dosage of NAC: Studies of NAC for many different conditions have used doses ranging from 500 mg to up to 20 g/day

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