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Longer circulation times are preferable for brain delivery strategies, with neutral and zwitterionic NPs showing slower clearance from the bloodstream compared with negatively and positively charged NPs, which instead presented shorter half-lives ( Altogether, polymer-based NPs represent a promising and competitive alternative to other conventional carbon-based and bio-based nanostructures eligible for potential clinical applications, such as fullerene, carbon dots (CDs) and nanotubes as well as liposomes (Faiyaz et al., 2021)