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Increased aspartate aminotransferase and alanine aminotransferase are observed in nearly one third of patients treated with propylthiouracil, and the rise is usually dose-related) [6]

Another mitochondria localized member of the folate metabolizing enzymes is methylene tetrahydrofolate dehydrogenase (NADP + dependent) 1-like which is encoded by the MTHFD1L gene