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1. Reproductive signalling pathways

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The proliferation and activation of T cells are associated with a decrease in extracellular GSH levels that subsequently result in a reduction of intracellular GSH levels (87)

For instance, EVs from cumulus cells carry miR-224, which targets Smad4 in oocytes to promote their maturation ( In the male reproductive system, EVs from Sertoli cells (Sertoli-EVs) provide vital support to developing germ cells in the seminiferous tubules, delivering nutrients, miRNAs, and proteins essential for spermatogenesis (James et al., 2020