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267 While there is a need in clinical research to enroll a more homogeneous patient population, this approach raises concerns about the clinical relevance of such studies for the truly heterogeneous IC/BPS population

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Role of 1C Metabolism in Redox Balance in Relation to Aging The redox theory of aging presents an intriguing perspective on how longevity may be influenced by the cellular redox state, specifically through the ratios of GSH (glutathione) to GSSG (oxidized glutathione) and of NADP+ to NADPH [129]