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[1] A frequently employed regimen involves applying approximately 1-2 mL of the 0.5 % solution to affected scalp regions once to twice daily, preferably on clean, dry skin in the evening

Due to this stipulation, it is possible that the amount of time participants consumed alcohol was diminished and, as such, the hangover symptoms experienced by the participants the following morning were not as severe as it would have been if they had continued drinking later in the evening

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The B7:CD28 family and friends: Unraveling coinhibitory interactions