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It has been documented that iodide excess increases the generation of ROS and ICAM-1 expression in cultures of NOD.H2 h4 mouse thyrocytes, and that the antioxidant diphenyleneiodium, an inhibitor of NADPH oxidase, reduced both phenomena [177]

Nguyen NT, Umbaugh DS, Smith S, et al

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Figure 1 Culturing in Ringer Solution at Low Hematocrit Increases the Baseline Levels of PS Exposure and Hemolysis in Erythrocytes To test the influence of specific culture conditions on baseline levels of eryptosis, and in the absence of any drug, nave erythrocytes were incubated in either Ringer solution (at 0.4 or 4% hematocrit) or in cRPMI at 4% hematocrit ( Figures 2A, B )