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In a potential diagnostic flowchart (Fig

Mechanism of action against RA Anti-inflammation and anti- oxidation COX-2, a key mediator in the inflammatory process, catalyzes the hydrolysis of glycerophospholipids to release arachidonic acid, which is converted to PGs, including prostacyclin, thromboxane A2, PGE2 and PGD2 during inflammation (185)

The conversion of R5P to PRPP, catalyzed by PRPS, is a process that limits the rate of nucleotide synthesis

These findings imply that emodin protects hepatocytes from APAP-induced liver damage by activating Nrf2-mediated antioxidant stress pathways, inhibiting the NLRP3 inflammasome, and downregulating the cGAS-STING signaling pathway (Shen et al., 2022)