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Melatonins use as an antioxidant possibly was a result of the Great Oxidative Event during which atmospheric oxygen rose profoundly necessitating the need for molecules that were capable of neutralizing toxic oxygen derivatives, i.e., free radicals

The evidence is clear

The original mouse study used roughly 3 weeks of alternating-day treatment

Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A (2020) Effects of l-carnitine supplementation on weight loss and body composition: a systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis