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Collectively, co-targeting metabolic dependencies (e.g., glutaminase inhibitors, ammonium scavengers) and death evasion mechanisms (e.g., ferroptosis inducers, ATF6 inhibitors) may overcome therapeutic resistance, with preclinical validation urgently needed for strategies combining autophagy modulation (AMPK/mTOR/ULK1 targeting), ferroptosis potentiation (system Xc blockade), and stromal disruption (CAF-derived glutamine inhibition) (205, 206)

Predicted performance of the MIRI coronagraphs

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Patients are getting what purport to be these substances, or are using drugs that are made with research-grade active ingredients, and I almost expect any day now theres going to be some serious patient adverse event or a series of patients who are made ill or worse by taking batches of these drugs that were not made to FDA standards or with active ingredients that are not made to FDA standards, Brunner said