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Unlike the conventional small molecule inhibitors, the PROTAC technology possesses its unique catalytic mode of action

This method achieved 100% accuracy in distinguishing patients with cancer from healthy donors, demonstrating its potential for early cancer diagnosis and treatment [352]

Since activating the glyoxylate shunt likely keeps the peroxisomal glyoxylate and hydroxypyruvate at manageable levels, the CO 2 release in hpr1 could be suppressed by defective GLYR1