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lean people Good things straight away in lean people Takes many weeks to start showing up in obese patients as they first need to fix some things Cannabinoids : Recent study has shown that THC can reduce the accumulation of amyloid beta (move up) Patients at hospital after TBI (moderate to severe) with highest levels of THC were least likely to die (dose dependent effect) In mice: given low THC dose 48-hours before TBI or 1-7 days after Dramatic neuro-inflammatory pathway 2 types of Cannabinoids receptors in the brain, CB1 andCB2 CB1 : Found on neurons Recent study showed agonizing CB1 lead to long term potentiation Learning something new enhances a neuronal signal help learn long term CB1 gets ride of the inhibitory, unless antagonized by amyloid beta May be some acute effect on short term memory and might be a tradeoff benefit for long term potentiation CB2 : On microglia- immune cells in the brain Cannabinoids in CB2 prevent the immune cells from activates and creating neuro-inflammation Unclear how More research now as $$$$ is involved in Colorado, etc