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Signs to look out for include loss of control over substance use or behavior, continued use despite negative consequences, cravings for the substance or behavior, tolerance, and withdrawal symptoms when not using the substance or engaging in the behavior

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Deacon and Valentiner (2000) [46] conducted a study that examined co-morbid panic attacks and substance use in a non-clinical sample of young adults who experienced regular panic attacks

SAP9 and SAP10 are involved in the mechanism of adhesion to host cells [21]