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Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway

Hemorrhagic transformation occurs through a disruption in tight junction proteins, and investigations into this underlying mechanism found that dysregulated extracellular proteolysis in the vascular matrix after tPA contributes to hemorrhagic transformation (Chandler et al., 1990

The last quarter also witnessed the introduction of 14 molecules with first-time DMFs

Elez E, Yoshino T, Shen L, Lonardi S, Cutsem EV, Eng C, Kim TW, Wasan HS, Desai J, Ciardiello F, Yaeger R, Maughan TS, Van K Morris II, Wu C, Usari T, Laliberte RJ, Dychter SS, Zhang X, Tabernero J, Kopetz S