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control, 1307)

Acute pancreatitis (AP) has increased in incidence in the last 10 years [2]

This suggests that immune dysregulation-induced gut microbiota dysbiosis and activation of the kynurenine pathway cause acute tryptophan depletion in the gut

In particular, they also acknowledge Mike Stubbins, Julia Perry, Sarah Bujac, David Campbell (at GSK currently or at the time when the study was performed), John Blundell (Leeds University) and Evleen Mann (Yorkshire Centre for Eating Disorders), for their fundamental contribution to the realization of this study