Wen W, Xu Y, Qian W, Huang L, Gong J, Li Y, et al
Ibutamoren (MK-677) Ibutamoren is a growth hormone secretagogue (GHS) that mimics ghrelin, a hunger-related hormone, to stimulate a sustained release of GH and Insulin-like growth factor 1 (IGF-1)
Activation of large-conductance (BK Ca ) and small-conductance (K Ca ) K + channels, as well as ATP-sensitive K + (K ATP ) channels, induces K + efflux, reducing Ca 2+ entry through voltage-gated calcium channels (VGCCs), leading to pericyte hyperpolarization and increased CBF [93]
166,167 TNF treatment promotes the expression of CD38 168 Thus, an increase in inflammation or senescence through inflammatory cytokines may induce CD38 expression during aging