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Some people find that anticipation alone can evoke taste changes before the medication has even had time to circulate

The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

Initially, some patients might need weekly injections, while others might benefit from monthly maintenance dosages

Most findings for both MOTS-c and 5-Amino-1MQ come from animal models (primarily mice)