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itterson & Tolan, C

Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior

TLC-2716 was well tolerated and improved atherogenic lipid parameters in healthy individuals Given the favorable efficacy and toxicological profile in preclinical species, a randomized, placebo-controlled phase 1 clinical trial of TLC-2716 was conducted in humans (ClinicalTrials.govNCT05483998, from 27 July 2022 to 18 June 2023