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found that uridine supplementation increases O-GlcNAcylation levels of insulin receptor substrates (IRS), Akt, mammalian target of rapamycin (mTOR) and p70S6 kinase (p70S6K), which are key components of insulin signaling propagation and modification in liver ( 6.3 Uridine and vascular complications of diabetes mellitus Uridine adenosine tetraphosphate (Up4A), a synthetic product of uridine, is an endothelium-derived vasoconstrictive factor (EDCF)