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Telomere shortening leads to cell cycle arrest and apoptosis, which underlie tissue degeneration, immune decline, and organ dysfunction

Infectious and environmental factors include chronic infections, smoking, heavy alcohol use, and certain toxins that increase risk

Key Findings: Asian participants: 21.3% mean weight loss with CagriSema (similar to overall population) Safety profile consistent across ethnicities GI tolerability similar but potentially lower discontinuation rates in Asian populations Clinical Significance: Supports global applicability of cagrilintide-based therapies across diverse populations