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In addition, iron and glutamate interact, as iron is involved in the synthesis of glutamate by activating cytosolic aconitase enzyme [133] and glutamate can increase the total brain iron content by making it easier for iron to enter the cell through the upregulation of DMT1

[DOI] [PubMed] [Google Scholar] [102].Murata Y, Amao M, Yoneda J, Hamuro J

2, GPT transfers nitrogen from glutamate to pyruvate to produce alanine and -KG

Oxid Med Cell Longev 2021(1):9971885 Delgado-Martn B, Medina M (2020) Advances in the knowledge of the molecular biology of glioblastoma and its impact in patient diagnosis, stratification, and treatment