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However, successful clinical translation will require addressing persistent challenges, including biosafety, biodistribution, tumor heterogeneity, and large-scale manufacturability

In addition, diabetes alters the antioxidant capacity of the heart, which is shown in the decreases in enzymatic (catalase, superoxide dismutase, glutathione peroxidase etc.) and non-enzymatic antioxidant defenses (vitamins A, E, or C) [140]

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