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The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity

have greater circulating levels of testosterone represents an evolutionarily novel spike, Trumble said

A third problem lies in batch variation and lack of standardization: Plant extracts are compositionally complex, with unstable ratios of active components, making it difficult to establish clear doseresponse relationships

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