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4.2 Co-regulation of mitochondrial biogenesis and mitochondrial dynamics A crosstalk exists between mitochondrial biogenesis and mitochondrial fission/fusion

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Moreover, PTEN loss, a common event in CRPC, enhances dependency on p110-mediated LPA (unspecified species) signaling in a mouse model of prostate tumorigenesis (69), raising the possibility that PTEN deficiency might indirectly augment the LPA pathway, though direct transcriptional regulation has not been demonstrated

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