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The data is clear: Nicotine activates POMC neurons, reducing hunger (Mineur et al., 2011) Nicotine raises energy expenditure ~10% (Hofstetter et al., 1986) Quitting nicotine causes ~4.67 kg weight gain at 12 months (Aubin et al., 2012) 80% of quitters gain weight (Aveyard et al., 2012) NRT delays but doesn't prevent post-quit weight gain (Farley et al., 2012) Vaping doesn't "make you lose weight." Nicotine does modestly, temporarily, and at a cost that includes physical dependence, cardiovascular stress, and inevitable weight rebound when you stop

Cardiovascular research, 119(1), 94111

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