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Free Radic Biol Med 27:11141121 Martin C, Dubouchaud H, Mosoni L, Chardigny JM, Oudot A, Fontaine E, Vergely C, Keriel C, Rochette L, Leverve X, Demaison L (2007) Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius

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106 Mechanisms linking obesity and OA extend beyond mechanical load to include pro-inflammatory factors secreted by adipose tissue, such as leptin and TNF-, which promote OA progression by activating immune responses