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Brakuje im wysokiej jakoci bada klinicznych, ich bezpieczne dawkowanie jest nieznane, a organy regulacyjne (takie jak FDA) ostrzegaj przed ryzykiem zanieczyszcze i niebezpiecznych reakcji immunologicznych

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However, during the chronic inflammation, the glial activation causes an increase of ROS production and other neurotoxic mediators, leading a neuronal damage [52]