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doi: 10.1152/jn.1992.67.5.1385

In addition, T2D is the result of a complex interaction of environmental and genetic factors, being difficult to establish the role of each one in the pathogenesis of diabetes and in the levels of IGF-1

173 , 338 , 383 , 384 Some other studies indicate Hispanic older adults are about one and onehalf times as likely to have Alzheimer's or other dementias as White older adults, 384 , 385 , 386 though others have shown similar prevalences among Hispanic older adults and White older adults

It is thought that over time, the disease shifts from an early hypermetabolic state to a hypometabolic state with decreased metabolites (251) and reduced energy production (59), correlating with patient clinical profiles (185)