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Cannon RD, Lamping E, Holmes AR, Niimi K, Baret PV, et al

To address this limitation, hydrogels incorporated with metal-based nanozymes exhibiting CAT-like activity, such as copper selenide NPs or MOFs, can sustainably decompose endogenous H 2 O 2 abundantly present in the TME to generate oxygen in situ , thereby effectively alleviating tumor hypoxia

Published phase 3 trials including OASIS 1 (Knop et al., 2023) show that even low absolute bioavailability can be clinically meaningful if the drug is potent enough and the dose is calibrated accordingly

Exposure to cigarette smoke altered the cytoarchitecture and anti-oxidant activity of the frontal cortex in Wistar rats